Galaxolide and tonalide modulate neuroendocrine activity in marine species from two taxonomic groups

Galaxolide (HHCB) and tonalide (AHTN) are polycyclic musk compounds (PMCs) used in household personal care products that have been included on the list as emerging contaminants of environmental concern due to their ubiquity aquatic terrestrial environments. There still exists a dearth information neurotoxicity endocrine disrupting effects these contaminants, especially for marine estuarine species. Here, we assessed neuroendocrine HHCB AHTN using adult clams, Ruditapes philippinarum, yolk-sac larvae sheepshead minnow, Cyprinodon variegatus. The clams were treated with concentrations (0.005–50 ?g/L) each compound 21 days. Meanwhile, minnow exposed 0.5, 5 50 ?g/L 3 Enzyme activities related (acetylcholinesterase - AChE), function (cyclooxygenase COX), energy reserves (total lipids TL) R. philippinarum. Gene expression levels cyp19 vtg1 measured C. variegatus qPCR. Our results indicated induction AChE COX while exposure significantly inhibited COX. was downregulated versus control. this study demonstrate might pose neurotoxic coastal ecosystems.